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Peptide Directory

Category · 11 peptides

Skin, Hair & Cosmetic

Peptides studied for collagen synthesis, skin remodeling, wrinkle reduction, and hair growth.

AHK-CuPreclinical
A synthetic copper-chelating tripeptide (Ala-His-Lys) positioned as the hair-follicle-focused cousin of GHK-Cu, researched for follicle stimulation and scalp vascularity.
  • Hair follicle stimulation
  • Scalp vascularity via VEGF
  • Reduced follicle miniaturization
dosing2 stacks
ArgirelineEmerging
A topical synthetic hexapeptide that softens dynamic expression lines by partially inhibiting the SNARE complex in facial muscles.
  • Dynamic wrinkle reduction
  • Partial SNARE / SNAP-25 inhibition
  • Non-injectable 'topical Botox' analog
3 studiesdosing2 stacks
Collagen PeptidesModerate
Orally-ingested hydrolyzed collagen peptides that supply connective-tissue building blocks and bioactive dipeptides, with the strongest evidence for skin elasticity, joint comfort, and tendon collagen synthesis.
  • Skin elasticity and hydration
  • Joint comfort and mild-moderate knee OA
  • Undenatured type II collagen (UC-II) joint support
6 studiesdosing5 stacks
GHK-CuModerate
A naturally occurring copper-binding tripeptide with the strongest cosmetic-skin evidence record of any peptide, driving collagen synthesis, wound healing, and broad gene-expression effects.
  • Collagen and elastin synthesis
  • Wound healing and tissue remodeling
  • Anti-aging skin appearance
9 studiesdosing5 stacks
LeuphasylPreclinical
A synthetic enkephalin-mimic pentapeptide marketed as a topical anti-wrinkle cosmetic active that theoretically relaxes facial expression lines.
  • Expression line reduction
  • Facial muscle relaxation
  • Enkephalin pathway modulation
1 studiesdosing1 stacks
MatrixylEmerging
A palmitoylated collagen-fragment pentapeptide used topically to mimic matrikine signaling and stimulate dermal collagen synthesis for anti-aging.
  • Collagen I and III synthesis
  • Fibronectin and extracellular matrix support
  • Wrinkle and fine-line reduction
1 studiesdosing1 stacks
Palmitoyl Tripeptide-1Moderate
A palmitoylated form of the copper-binding GHK tripeptide engineered for deep dermal penetration to stimulate collagen and matrix synthesis in anti-aging skincare.
  • Collagen synthesis
  • Skin firmness and anti-aging
  • Matrix support
2 studiesdosing1 stacks
PTD-DBMPreclinical
A cell-penetrating peptide designed to reactivate Wnt/beta-catenin signaling in hair follicles by disrupting the CXXC5-Dishevelled interaction, studied for hair regrowth.
  • Hair regeneration
  • Hair follicle activation
  • Wnt pathway modulation
RiginPreclinical
A palmitoylated tetrapeptide cosmetic active that suppresses IL-6-driven skin inflammation to protect the collagen matrix from age-related breakdown.
  • Anti-inflammatory (skin)
  • Extracellular matrix support
  • Wrinkle reduction
dosing1 stacks
SNAP-8Emerging
A topical anti-wrinkle octapeptide marketed as a needle-free, reversible 'topical Botox' that mimics the SNARE-inhibition mechanism of botulinum toxin.
  • Softening of dynamic expression lines
  • Reduction in wrinkle depth
  • Non-injectable, reversible anti-aging approach
dosing1 stacks
SYN-AKEPreclinical
A synthetic snake-venom-mimetic tripeptide marketed as a topical, reversible "botulinum-like" wrinkle relaxer.
  • Dynamic wrinkle reduction
  • Expression line softening
  • Muscle relaxation at the neuromuscular junction
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